Library / English Dictionary

MEGAKARYOCYTE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A large bone marrow cell; regarded as the source of blood platelets

Classified under:

Nouns denoting body parts

Hypernyms ("megakaryocyte" is a kind of...):

bone cell (a cell that is part of a bone)

Derivation:

megakaryocytic (of or pertaining to large bone marrow cells)

Credits

 Context examples: 

This allele, which encodes calcium and integrin-binding protein 1, is involved in megakaryocyte differentiation, integrin regulation, calcium binding and apoptosis.

(CIB1 wt Allele, NCI Thesaurus)

Also called PEG-rhMGDF and polyethylene glycosylated recombinant human megakaryocyte growth and development factor.

(PEG-MGDF, NCI Dictionary)

The recombinant human megakaryocyte growth and development factor (rHuMGDF) component of this formulation is a nonglycosylated, truncated form of the Mpl ligand.

(PEG Recombinant Human Megakaryocyte Growth and Development Factor, NCI Thesaurus)

A non-neoplastic, congenital or non-congenital disorder charcaterized by marked reduction or absence of megakaryocytes and thrombocytopenia.

(Amegakaryocytosis, NCI Thesaurus)

Megakaryocytes are smaller than normal and have hypolobated nuclei.

(Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, NCI Thesaurus/WHO)

It consists of blood vessel sinuses and a network of hematopoietic cells which give rise to the red cells, white cells, and megakaryocytes.

(Bone marrow, NCI Thesaurus)

An undifferentiated cell which can undergo division and can give rise to either a megakaryocyte or a cell in the erythrocytic series.

(Bone Marrow Stem Cell with Potential for Megakaryocytic and Erythroid Differentiation, NCI Thesaurus)

This protein plays a role in calcium binding, integrin activity regulation, apoptosis modulation and megakaryocyte differentiation.

(Calcium and Integrin-Binding Protein 1, NCI Thesaurus)

A primitive undifferentiated cell which can undergo division and can give rise to one of the early megakaryocytes.

(Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage, NCI Thesaurus)

Comment: may be designated as having features of a named human MDS; Morphologic dysgranulopoiesis, dyserythropoiesis, and/or dysplastic megakaryocytes (with or without increased immature forms/blasts)

(Mouse Myelodysplastic Syndrome, NCI Thesaurus/MMHCC)