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MEN2B syndrome
Pronunciation
A rare, genetic disorder that affects the endocrine glands and causes a type of thyroid cancer called medullary thyroid cancer, pheochromocytoma, and parathyroid gland cancer. It may also cause benign (noncancerous) tumors in the adrenal glands and growths around the nerves in the lips, tongue, lining of the mouth, and eyelids. Gastrointestinal symptoms and trouble with the spine or bones in the feet and thighs may also occur. MEN2B syndrome is caused by a mutation (change) in a gene called RET. Also called MEN2B, multiple endocrine adenomatosis type 2B, and multiple endocrine neoplasia type 2B syndrome. (NCI Dictionary)
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Human MEN wild-type allele is located in the vicinity of 11q13 and is approximately 8 kb in length. This allele, which encodes…
