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Metalloproteinase Inhibitor 3
Definition 1
Metalloproteinase inhibitor 3 (221aa, ~24 kDa) is encoded by the human TIMP3 gene. This protein is involved in metalloproteinase inhibition. (NCI Thesaurus)
Definition 2
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21 kD, nonglycosylated protein. TIMP-3 does not show a high degree of structural similarity unlike TIMP-1 and TIMP-2 which are structurally similar. However, it does possess a high degree of structural similarity with that of chicken TIMP-3 (ChIMP-3). Human TIMP-3 is of particular concern because of its potential role in cancer, arthritis, and eye diseases. (NLM, Medical Subject Headings)
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