| Library / English Dictionary |
METHOTREXATE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
Synonyms:
amethopterin; methotrexate; methotrexate sodium
Classified under:
Nouns denoting man-made objects
Hypernyms ("methotrexate" is a kind of...):
antimetabolite (an antineoplastic drug that inhibits the utilization of a metabolite)
immune suppressant drug; immunosuppressant; immunosuppressive; immunosuppressive drug; immunosuppressor (a drug that lowers the body's normal immune response)
Context examples:
A modified version of the NHL-BFM 90 regimen, employing a different methotrexate dosing schedule, used for the treatment of localized aggressive forms of childhood B-cell lymphoma, including lymphoblastic lymphoma.
(NHL-BFM-95 Regimen, NCI Thesaurus)
A regimen consisting of methotrexate, vinblastine, doxorubicin and cisplatin used for the treatment of advanced-stage bladder cancer.
(MVAC Regimen, NCI Thesaurus)
The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties.
(Methotrexate Sodium, NCI Thesaurus)
A prolonged maintenance regimen including tretinoin and methotrexate, with or without mercatopurine (6-MP), is also part of the treatment plan.
(COG-C9710 APL Regimen, NCI Thesaurus)
Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated.
(Edatrexate, NCI Thesaurus)
A regimen consisting of cisplatin, doxorubicin, and methotrexate used as an adjuvant treatment for localized childhood osteosarcoma.
(Cisplatin-Doxorubicin-Methotrexate Regimen, NCI Thesaurus)
It includes the drugs cyclophosphamide, methotrexate, and fluorouracil.
(CMF, NCI Dictionary)
A chemotherapy regimen consisting of cyclophosphamide, methotrexate, and fluorouracil, which may be used in the adjuvant setting for the treatment of nonmetastatic breast cancer or alone for the treatment of metastatic breast cancer.
(CMF regimen, NCI Thesaurus)
It is a bacterial enzyme that breaks down proteins and other substances, such as methotrexate.
(carboxypeptidase-G2, NCI Dictionary)
Intrathecal cytarabine and methotrexate are included in this regimen as either prophylaxis or treatment for central nervous system (CNS) involvement.
(CODOX-M/IVAC Regimen, NCI Thesaurus)
