Methotrexate-E Therapeutic Implant

An injectable collagen matrix gel containing the antimetabolite methotrexate and the sympathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of methotrexate into the tumor tissue and reduce dispersion to the surrounding tissues thereby enhancing the local concentration of methotrexate and increasing its anti-tumor activity. Intratumoral injection of methotrexate combined with epinephrine may potentially increase chemotherapeutic efficacy compared to systemic administration and reduce systemic toxicity and side effects. (NCI Thesaurus)

YOU MAY ALSO LIKE

Methotrexate-Associated Lymphoproliferative Disorder

A lymphoproliferative disorder that develops in patients who are immunosuppressed with methotrexate. This disorder is often Epstein-Barr virus positive, and morphologically it…

Methotrexate Sodium

The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase,…

Methotrexate

A drug used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Methotrexate stops cells from…

Methodology

In medicine, the rules and procedures for doing research and evaluating results.

Method, LOINC Axis 6

The process by which an observation value was obtained. Example methods include: weighing, use of a mass spectrometer, use of an…

Method of Termination of Life

The mechanism by which a life is ended.