Methoxsalen With Ultraviolet A Therapy

Definition 1

Strong evidences have indicated causal association between 8-methoxypsoralen with UVA (PUVA) treatment and non-melanocytic skin patients with psoriasis. 8-Methoxypsoralen alone did not alter the incidence of new skin cancer development in a 2-year study. In a large number of studies, 8-Methoxypsoralen in combination with ultraviolet A radiation induced chromosomal aberrations, sister chromatid exchanges, mutation, DNA damage and DNA cross-links in human cells in vitro. This treatment is classified as carcinogenic to Human by IARC. (NCI Thesaurus)

Definition 2

A type of photodynamic therapy used to treat skin conditions such as psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. The patient receives psoralen (a drug that becomes active when it is exposed to light) by mouth or applied to the skin, followed by ultraviolet A radiation. Psoralen and ultraviolet A therapy may increase the risk of getting skin cancer. (NCI Dictionary)

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