Micellar Nanoparticle-Encapsulated Cisplatin NC-6004

A nanoparticle-based prodrug formulation consisting of polymeric micelles incorporating the inorganic platinum agent cisplatin with potential antineoplastic activity. In micellar nanoparticle-encapsulated cisplatin NC-6004, cisplatin forms a polymer-metal complex with hydrophilic polyethylene glycol poly(glutamic acid) block copolymers by attaching to the micelle inner core consisting of the hydrophobic polyamino acids. Upon cell entry and release from the polymer-metal complex, cisplatin forms highly reactive, charged platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-linking, DNA-protein cross-linking and, subsequently, tumor cell apoptosis and growth inhibition. Due to the hydrophilic nature of polyethylene glycol, this formulation increases the water-solubility of cisplatin and decreases the nephrotoxicity and neurotoxicity associated with the administration of cisplatin alone. (NCI Thesaurus)

YOU MAY ALSO LIKE

MICB wt Allele

Human MICB wild-type allele is located in the vicinity of 6p21.3 and is approximately 16 kb in length. This allele, which encodes…

MICB Gene

This gene plays a role in activation of the immune cytolytic response.

Micafungin Sodium

The sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal…

Micafungin

A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides,…

MIBG scan

A procedure used to find neuroendocrine tumors, such as neuroblastomas and pheochromocytomas. A small amount of a substance called radioactive MIBG is…

MIB1 wt Allele

Human MIB1 wild-type allele is located in the vicinity of 18q11.2 and is approximately 130 kb in length. This allele, which encodes…