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MICROSOMAL
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I. (adjective)
Sense 1
Meaning:
Of or relating to microsomes
Classified under:
Relational adjectives (pertainyms)
Pertainym:
microsome (a tiny granule in the cytoplasm that is where protein synthesis takes place under the direction of mRNA)
Derivation:
microsome (a tiny granule in the cytoplasm that is where protein synthesis takes place under the direction of mRNA)
Context examples:
A measurement of the liver kidney microsomal type 1 antibody in a biological specimen.
(Liver Kidney Microsomal Type 1 Antibody Measurement, NCI Thesaurus/CDISC)
The determination of the amount of liver kidney microsomal type 1 IgA antibody present in a sample.
(Liver Kidney Microsomal Type 1 IgA Antibody Measurement, NCI Thesaurus)
A microsomal triglyceride transfer protein inhibitor, approved in veterinary use for weight loss and reduction of hyperlipidemia in dogs.
(Mitratapide, NCI Thesaurus)
Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-).
(Nifurtimox, NCI Thesaurus)
A synthetic derivative of benzodioxole and used as an insecticide synergist, Piperonyl Butoxide enhances the active properties of pyrethrin, pyrethroid, rotenone, and carbamate pesticide ingredients by inhibiting insect microsomal enzyme detoxification activity.
(Piperonyl Butoxide, NCI Thesaurus)
Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.
(Ketoconazole, NCI Thesaurus)
A measurement of the liver kidney microsomal type 1 IgA antibodies in a biological specimen.
(Liver Kidney Microsomal Type 1 IgA Antibody Measurement, NCI Thesaurus/CDISC)
Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
(Aflatoxin B1, NLM, Medical Subject Headings)
A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B ) in the assembly of very-low-density lipoprotein.
(Lomitapide, NCI Thesaurus)
Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis.
(Low Density Lipoprotein Receptor, NCI Thesaurus/LocusLink)
