| Health / Medical Topics |
Mismatch Repair Pathway
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. (NCI Thesaurus/KEGG)
YOU MAY ALSO LIKE
Mismatch repair endonuclease PMS2 (862 aa, ~96 kDa) is encoded by the human PMS2 gene. This protein plays a role in DNA…
The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and…
A 25 nucleotide probe with a sequence mismatch to its target at position 13 used for measuring non-specific binding in analysis of…
Describes how a reporter varies from its ReporterCharacteristics sequence(s) or how a Feature varies from its Reporter sequence. (caMAGE)
A failure to correspond or match; to match unsuitably or inaccurately.
