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Mitoguazone dihydrochloride
Pronunciation
Definition 1
A substance being studied in the treatment of some leukemias and lymphomas. It blocks the growth of cells and may cause cancer cells to die. It is a type of polyamine synthesis inhibitor. (NCI Dictionary)
Definition 2
The hydrochloride salt of a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI Thesaurus)
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