| Health / Medical Topics |
MKC-1
Definition 1
An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus. (NCI Thesaurus)
Definition 2
A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors. (NCI Dictionary)
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A substance that occurs as part of a mixture substance.
A substance consisting of two or more substances mixed together (not in fixed proportions and not with chemical bonding).
Any mixing operation not otherwise specified.
