MLL/ABI1 Fusion Gene

A fusion gene that results from a chromosomal translocation t(10;11)(p11.2;q23) which fuses either exon 6 or 7 of the MLL gene to nucleotide 433 of the ABI1 gene. This rearrangement is associated with acute monoblastic leukemia, acute myelomonocytic leukemia and acute myeloid leukemia (NCI Thesaurus)

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MLL-AF4 Fusion Protein Expression

Expression of a fusion protein that results from the insertion mutation ins(5;11)(q31;q13q23), which involves the human genes MLL and AFF1 and is…

MLL wt Allele

Human MLL wild-type allele is located in the vicinity of 11q23 and is approximately 89 kb in length. This allele, which encodes…

MLL Gene

This gene is involved in transcriptional regulation and alterations in the gene are associated with acute lymphoblastic leukemia.

MLH3 wt Allele

Human MLH3 wild-type allele is located in the vicinity of 14q24.3 and is approximately 35 kb in length. This allele, which encodes…

MLH3 Gene

This gene plays a role in DNA mismatch repair and is associated with hereditary nonpolyposis colon cancer.

MLH1 wt Allele

Human MLH1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 57 kb in length. This allele, which encodes…