| Health / Medical Topics |
MLL/AFF1 Fusion Protein
A fusion protein (~2250 aa, ~240 kDa) encoded by the MLL/AFF1 fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to the C-terminal half of the AF4/FMR2 family member 1 protein. (NCI Thesaurus)
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A fusion gene (~12 kb) that results from a chromosomal translocation t(4;11)(q21;q23) which fuses the 5' half of the MLL gene to…
A fusion protein encoded by the MLL/ABI1 fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL…
A fusion gene that results from a chromosomal translocation t(10;11)(p11.2;q23) which fuses either exon 6 or 7 of the MLL gene to…
Expression of a fusion protein that results from the insertion mutation ins(5;11)(q31;q13q23), which involves the human genes MLL and AFF1 and is…
Human MLL wild-type allele is located in the vicinity of 11q23 and is approximately 89 kb in length. This allele, which encodes…
This gene is involved in transcriptional regulation and alterations in the gene are associated with acute lymphoblastic leukemia.
