MLN2704

Definition 1

A substance that is being studied in the treatment of prostate cancer. It belongs to the family of drugs called antibody drug conjugates. Also called MLN591DM1. (NCI Dictionary)

Definition 2

An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. (NCI Thesaurus)

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