MLN51 Protein

Encoded by human MLN51 Gene, ubiquitous cytoplasmic 76.3 kD MLN51 Protein contains 703 residues that share no significant homology with any known protein. MLN51 is well conserved between vertebrate and invertebrate species suggesting an important function. The N-terminal half contains putative nuclear localization signals and a coiled-coil domain that seems to promote MLN51 oligomerization. The C-terminal half contains a SH2 and four SH3 binding motifs and may regulate nuclear localization. The unusual combination of protein-protein interaction domains in MLN51 suggests a possible nucleo-cytoplasmic function. Malignant breast carcinoma epithelial cells exhibit over expression of MLN51. (from Oncogene 2002; 21:4422, SWISS-PROT, LocusLink, and NCI) (NCI Thesaurus)

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