| Health / Medical Topics |
Monoclonal Antibody RAV12
Definition 1
A chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate epitope (glycotope) expressed on various human carcinomas with potential antineoplastic activity. Following binding, monoclonal antibody RAV12 disrupts sodium channels of tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss of membrane integrity, and cell death. (NCI Thesaurus)
Definition 2
A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. It binds to a carbohydrate (sugar) molecule that is found on gastric, colon, pancreatic, prostate, ovarian, breast, and kidney cancer cells. (NCI Dictionary)
YOU MAY ALSO LIKE
An IgG murine monoclonal antibody directed against the ganglioside GD3 glycolipid, located in the cell membranes of some tumor cells. Monoclonal…
The Monoclonal Antibody Production Shared Resource is responsible for monoclonal antibody generation and production, provides other antibody-related products and services to support…
A recombinant monoclonal antibody (OVB3) directed against human ovarian cancer linked with an exotoxin derived from the bacterium Pseudomonas aeruginosa. The…
A mouse monoclonal IgG3 antibody that reacts with the cytoplasm and cell surface of colonic adenocarcinoma and shows restricted normal tissue…
A synthetic immunotoxin consisting of the murine monoclonal antibody N901 conjugated with toxin-blocked ricin (BR). Monoclonal antibody N901-BR binds to CD56,…
The F(ab)2 fragment of monoclonal antibody (MoAb) MX35 that recognizes a 95 kD glycoprotein with homogeneous distribution on 80% of ovarian tumor…
