| Health / Medical Topics |
Monoubiquitination
The type of ubiquitin modification determines the functional consequences for the modified protein. Monoubiquitination does not serve as a proteasome targeting signal, but plays other distinct roles. Target proteins are monoubiquitinated on one or more lysine residues, which serve as a signal for intracellular sorting as well as endocytosis of cell-surface proteins. Monoubiquitination of cell-surface receptors serves as a signal to target them to lysosome, where they are degraded by lysosomal proteases. (From PMID and NCI) (NCI Thesaurus)
YOU MAY ALSO LIKE
Therapy that uses one type of treatment, such as radiation therapy or surgery alone, to treat a certain disease or condition. In…
A chromosomal abnormality consisting of the absence of one of the copies of chromosome 7 in somatic cells.
A cytogenetic aneuploidy abnormality that refers to the presence of one chromosome 5 only. It is associated with the development of refractory…
A rare syndrome that is characterized by the partial deletion of the long arm of chromosome 13. Signs and symptoms include low…
A chromosomal abnormality consisting of the absence of a copy (homolog) of chromosome 13.
A chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number.
