Mouse Myeloid Proliferation

Definition 1

Comment: Intended to encompass diseases more closely related to human myelodysplastic/myeloproliferative or myeloproliferative diseases than to human myelodysplastic syndromes. Myeloid proliferations (nonreactive) may be morphologically indistinguishable from reactive processes. Reactive cause for increased numbers of nonlymphoid hematopoietic cells should be considered. By definition, this diagnosis is for lesions that are nonreactive, persistent, and genetically determined. (NCI Thesaurus/MMHCC)

Definition 2

Disorder is not a myeloid dysplasia [if a disorder satisfied criterion 1 for myeloid proliferation (non-reactive) but also fulfills criteria for myeloid dysplasia the diagnosis of myeloid dysplasia should be applied]. (NCI Thesaurus/MMHCC)

Definition 3

Mice exhibit increased non-lymphoid hematopoietic cells as evidenced by any combination of; A: Erythrocytosis, leukocytosis of myeloid cells, and/or thrombocytosis/circulating megakaryocytes B: Increased non-lymphoid hematopoietic cells in spleen and/or bone marrow. (NCI Thesaurus/MMHCC)

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