| Health / Medical Topics |
Mouse Precursor B Cell Lymphoblastic Lymphoma and Leukemia
Definition 1
Frequent in some GEM and mice infected with acutely transforming MuLV; Necropsy findings: Splenomegaly, generalized lymphadenopathy, usually with extensive spread to liver, kidney, and lungs, sometimes to meninges with skull exostoses and hind limb paralysis; leukemic form in about one third of cases; Cell size: Medium, uniform; Cytoplasm: Scant; Nuclei: Round or ovoid; chromatin fine; Nucleoli: Variable, often single, central and prominent but sometimes small and multiple; Mitoses: Numerous; Pattern: Diffuse, sometimes starry sky because of apoptosis. (NCI Thesaurus/MMHCC)
Definition 2
Phenotype: Immature B cell, sIg-. B220+ CD19+ CD43+ CD43- Ly6d (ThB)+ Tdt+; Molecular: Clonal precursor B cell, IgH G/R, IgK G/G; Characteristic: High grade; Presumed cell of origin: Bone marrow precursor B-cell lymphoblast; Differential diagnosis: Histologically and cytologically indistinguishable from most pre-T lymphoblastic lymphoma, Burkitt lymphoma, and Burkitt-like lymphoma, but CD3- sIg- TdT+; Human counterpart and commentary. (NCI Thesaurus/MMHCC)
Definition 3
Precursor B-cell lymphoblastic lymphoma and leukemia. The use of the same name in the 2 species seems appropriate because of highly similar histologic, cytologic, phenotypic, and molecular features; Occurrence: Uncommon spontaneous neoplasm of inbred mice. (NCI Thesaurus/MMHCC)
YOU MAY ALSO LIKE
