MRE11/RAD50 Double-Strand Break Repair Complex

The MRE11/RAD50 double-strand break repair complex consists of 5 proteins: Nibrin, p200, p400, MRE11, and RAD50. This complex possesses manganese-dependent single-stranded DNA endonuclease and 3-prime to 5-prime exonuclease activities. In mammalian cells, this complex is important for double-strand break repair, meiotic recombination, and telomere maintenance. It functions in diverse aspects of the cellular response to double strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair. (NCI Thesaurus/from OMIM)

YOU MAY ALSO LIKE

MRC2 wt Allele

Human MRC2 wild-type allele is located in the vicinity of 17q23.2 and is approximately 66 kb in length. This allele, which encodes…

MRC2 Gene

This gene is involved in extracellular matrix remodeling.

MRC1 wt Allele

Human MRC1 wild-type allele is located in the vicinity of 10p12.33 and is approximately 102 kb in length. This allele, which encodes…

MRC1 Gene

This gene is involved in endocytosis of glycoproteins by macrophages.

MRAS wt Allele

Human MRAS wild-type allele is located in the vicinity of 3q22.3 and is approximately 58 kb in length. This allele, which encodes…

MRAS Gene

This gene is involved in development and plays a role in signal transduction.