MSI

A change that occurs in the DNA of certain cells (such as tumor cells) in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different than the number of repeats that was in the DNA when it was inherited. The cause of MSI may be a defect in the ability to repair mistakes made when DNA is copied in the cell. Also called microsatellite instability. (NCI Dictionary)

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MSH6 wt Allele

Human MSH6 wild-type allele is located within 2p16 and is approximately 24 kb in length. This allele, which encodes DNA mismatch repair…

MSH6 Gene

This gene is involved in mismatch repair and plays a role in several cancers.

MSH4 wt Allele

Human MSH4 wild-type allele is located within 1p31 and is approximately 116 kb in length. This allele, which encodes MutS protein homolog…

MSH4 Gene

This gene is involved in DNA repair and meiotic recombination.

MSH3 wt Allele

Human MSH3 wild-type allele is located within 5q11-q12 and is approximately 222 kb in length. This allele, which encodes DNA mismatch repair…

MSH3 Gene

This gene plays a role in DNA mismatch repair and has been implicated in several cancers.