MSM/Glucosamine

A combination preparation of glucosamine, a hexosamine sugar polymer, and methyl sulfonyl methane (MSM), a derivative of dimethyl sulphoxide, with anti-arthritic and anti-inflammatory activities. The mechanism of action has not yet been fully elucidated but addition of glucosamine to chondrocytes results in inhibition of proteoglycan catabolism. Glucosamine inhibits interleukin-1-induced production of inflammatory mediators (nitric oxide, prostaglandin E2), and inhibit aggrecanase activity, which results in preservation of proteoglycan and chondrocytes. Other studies have also shown glucosamine to reduce the generation of reactive oxygen species by macrophages, and inhibit lysosomal enzymes. MSM has been suggested to exert its analgesic effect by inhibiting pain impulses along type C nerve fibers, reducing inflammation and muscle spasms, as well as promoting blood flow, thereby promoting the healing of cartilage lesions. (NCI Thesaurus)

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