Mucin Peptide MUC-1

Definition 1

Mucin is expressed by most glandular epithelia. Tandem repeats characterize the core mucin protein, apomucin; variation of the protein derives from variation in the number of expressed repeats. Native forms of mucin are distinct in size and degree of glycosylation; factors other than the primary structure of apomucin may contribute to these characteristics. Many complex O-linked oligosaccharides are presumably added by glycosyltransferases. Expression is increased in the lactating breast and in breast, ovary, lung, and prostate malignancies. It is a serum marker for breast cancer. (NCI Thesaurus)

Definition 2

Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer. (NLM, Medical Subject Headings)

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