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Multidrug Resistance Process
Definition 1
Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins. (NCI Thesaurus)
Definition 2
Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective. (NCI Dictionary)
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