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Multiple Nucleotide Abnormalities
Point mutations at various locations in a DNA sequence from either a eukaryotic or prokaryotic organism that causes a base change which results in an amino acid change in the protein product. This alteration may affect the stability and/or activity of the protein. Multiple mutation abnormalities may be heritable or occur spontaneously. (NCI Thesaurus)
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The heavy chain, IgG, of the immunoglobulin is defective. This is the most common type of multiple myeloma (>50%).
The heavy chain of the immunoglobulin, IgE, is defective. This multiple myeloma subtype is extremely rare.
The heavy chain of the immunoglobulin, IgD, is defective. This multiple myeloma subtype is very rare (~1%).
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