Murine Follicular Dendritic Cells

Definition 1

Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs. These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells. (NCI Thesaurus)

Definition 2

Cells with extensive dendritic processes found in the B-cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the DENDRITIC CELLS associated with T-cells. Follicular dendritic cells have Fc receptors (RECEPTORS, FC) and C3b receptors (RECEPTORS, COMPLEMENT 3B), but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T-cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B-cells during an immune response. (From Herbert et al., Dictionary of Immunology, 4th ed) (NLM, Medical Subject Headings)

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