Health / Medical Topics

    Murine Lymphokine Activated Killer Cells

    Definition 1

    Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are interleukin-2-activated NK cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. LAK cells are used for adoptive immunotherapy in cancer patients. (NLM, Medical Subject Headings)

    Definition 2

    culturing lymphocytes in the presence of IL-2 results in the development of effector cells which are cytotoxic to tumor cells; autologous LAK cells have been used in adoptive immunotherapy in cancer treatment. (NIH CRISP Thesaurus)




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