Proximity to muscle cells may promote spread of prostate cancer cells

Proximity to nearby muscle cells may make prostate cancer cells more likely to invade nearby tissues and spread to other organs, according to an early study by researchers at the National Institutes of Health.

Prostate cancer cells (square) near skeletal (oblong) and smooth (oval) muscle cells respond to Interleukins 4 and 13 (IL4/13) by producing annexin A5 and syncytin 1 (Syn1 & AnxA5) and fusing. Fused cells (starburst) develop increased capacity to invade tissue and spread. Photo: Eunice Kennedy Shriver/National Institute of Child Health and Human Development/National Institutes of Health

The presence of muscle cells appears to make cancer cells more likely to fuse two or more cancer cells into a single cell, thereby increasing their invasiveness and ability to spread.

Researchers grew human prostate cancer cells in laboratory dishes along with human muscle cells—stand-ins for the smooth muscle surrounding the prostate gland and the striated muscle of the urethral sphincter at the base of the prostate.

The muscle cells secreted interleukins 4 and 13, cellular proteins that stimulated the cancer cells to produce two additional proteins, annexin A5 and syncytin 1, which triggered the cancer cells to fuse together.

Testing revealed that the fused cells developed characteristics of more malignant cells, which are more likely to invade surrounding tissues and spread to other parts of the body. The researchers note that drugs to inhibit annexin A5 and syncytin 1 could be studied for their potential to treat prostate cancer. (National Institutes of Health)

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