Mutation Abnormality

Definition 1

Any transmissible change in the genetic material of an organism, which can result from radiation, viral infection, transposition, treatment with mutagenic chemicals and errors during DNA replication or meiosis. The effects of mutation range from single base changes to loss or gain of complete chromosomes. As many of the simpler alterations to DNA may be repaired, such changes are only heritable once the change is fixed in the DNA by the process of replication. Mutations may be associated with genetic diversity or with pathologies including cancer. (NCI Thesaurus)

Definition 2

Any change in the DNA of a cell. Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment. Mutations can be harmful, beneficial, or have no effect. If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited. Certain mutations may lead to cancer or other diseases. (NCI Dictionary)

YOU MAY ALSO LIKE

Mutation

Any change in the DNA sequence of a cell. Mutations may be caused by mistakes during cell division, or they may be…

Mutated Ras Peptide

Point-mutation products of Ras proto-oncogene are found to associated with a broad spectrum of human carcinomas. Mutation locations are notably at…

Mutate

To change the genetic material of a cell. The changes (mutations) can be harmful, beneficial, or have no effect.

Mutant p53 Peptide Pulsed Dendritic Cell Vaccine

A cancer vaccine consisting of autologous dendritic cells which have been pulsed with a mutant p53 peptide. Vaccination with mutant p53 peptide…

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or…

Mutamycin

A drug used to treat advanced cancer of the stomach and pancreas that has not gotten better with other treatment. It is…