| Health / Medical Topics |
N-Desmethyltamoxifen
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from binding to the estrogen receptor. This may inhibit estrogen-associated signaling and tumor growth in estrogen-positive tumor cells. Conversion of N-desmethyltamoxifen from tamoxifen is catalyzed by cytochrome P-450 enzymes 3A4 and 3A5. N-desmethyltamoxifen is further hydroxylated, mainly by CYP2D6, to endoxifen, the major clinically active metabolite of tamoxifen. (NCI Thesaurus)
YOU MAY ALSO LIKE
N-cym protein (109 aa, ~12 kDa) is encoded by the human MYCNOS gene. This protein may play a role in embryonic…
N-chimaerin (459 aa, ~53 kDa) is encoded by the human CHN1 gene. This protein is involved in the regulation of signal…
Human Neural-cadherin is encoded by the CDH2 gene. The gene product is 906 amino acids and ~100kD in size. This protein plays…
A synthetic carcinogenic compound found in a variety of smokes and industrial products, N-butyl-N-4-hydroxybutyl nitrosamine is used in biomedical research to induce…
A substance that is used in cancer research to cause bladder tumors in laboratory animals. This is done to test new diets,…
A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase…
