Library / English Dictionary

NAD

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A coenzyme present in most living cells and derived from the B vitamin nicotinic acid; serves as a reductant in various metabolic processes

Synonyms:

NAD; nicotinamide adenine dinucleotide

Classified under:

Nouns denoting substances

Hypernyms ("NAD" is a kind of...):

coenzyme (a small molecule (not a protein but sometimes a vitamin) essential for the activity of some enzymes)

Credits

 Context examples: 

It is required by the body for the formation of coenzymes NAD and NADP.

(Niacin, NLM, Medical Subject Headings)

NAD(P)H-hydrate epimerase (288 aa, ~32 kDa) is encoded by the human APOA1BP gene.

(NAD(P)H-Hydrate Epimerase, NCI Thesaurus)

NAD(P)H dehydrogenase [quinone] 1 (274 aa, ~31 kDa) is encoded by the human NQO1 gene.

(NAD(P)H Dehydrogenase [Quinone] 1, NCI Thesaurus)

This reaction, in addition to producing lactic acid, also produces nicotinamide adenine dinucleotide (NAD) that is then used in glycolysis to produce energy source adenosine triphosphate (ATP).

(Lactic Acid, DL-, NCI Thesaurus)

Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis.

(Cladribine, NCI Thesaurus)

This agent displays selectivity activity towards both hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase).

(Apaziquone, NCI Thesaurus)

A synthetic derivative of nicotinamide adenine dinucleotide (NAD).

(Aminothiadiazole, NCI Thesaurus)

NR acts on the brain by normalizing levels of nicotinamide adenine dinucleotide (NAD+), a metabolite vital to cellular energy, stem cell self-renewal, resistance to neuronal stress and DNA repair.

(Compound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer’s disease, National Institutes of Health)

This allele, which encodes NAD(P)H-hydrate epimerase protein, plays a role in both NAD metabolism and apolipoprotein A-I binding.

(APOA1BP wt Allele, NCI Thesaurus)

When b-lap is activated by NAD(P)H:quinone oxidoreductase-1 (NQO1) this agent creates a futile oxidoreduction, generating highly reactive oxygen species (ROS) that results in DNA damage.

(Beta-lapachone Prodrug ARQ 761, NCI Thesaurus)