| Health / Medical Topics |
Nanoparticle-encapsulated Doxorubicin Hydrochloride
A formulation of nanoparticles encapsulating the hydrochloride salt form of the anthracycline antibiotic doxorubicin, with potential antitumor activity. Upon intravenous administration, doxorubicin intercalates DNA, interferes with the activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells. (NCI Thesaurus)
YOU MAY ALSO LIKE
The classification of discrete nanoparticle entities.
The structural motif of a nanoparticle that is defined by the spatial relationship of the constituent atoms.
A distinguishing feature present on the surface of a nanoparticle.
The production of small, stable particles whose size is measured in nanometers.
The measurement and description of information pertaining to the determination of the physical properties of nanoparticles. These analyses enable the quantification of…
A drug used to treat breast cancer that has come back or spread to other parts of the body. It is also…
