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NASCENT
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Being born or beginning
Example:
a nascent insurgency
Classified under:
Similar:
emergent; emerging (coming into existence)
dissilient (bursting open with force, as do some ripe seed vessels)
parturient (giving birth)
Antonym:
dying (in or associated with the process of passing from life or ceasing to be)
Derivation:
nascency (the event of being born)
Context examples:
Because the half-time of monoglucose in the nascent glycoproteins is about 2 min, the protein should be repeatedly reglycosylated by UDP-glucose: glycoprotein glucosyltransferase (UGGT) resulting in association with CNX.
(Endoplasmic Reticulum Degradation Pathway, NCI Thesaurus/BIOCARTA)
And the nascent development of treatments for microbiota-linked maladies operates under the idea that imbalances or deviations in the microbiome are the source of health problems, such as indigestion or Crohn's disease.
(Microbes are at work in our bodies, and researchers have figured out what they're up to, National Science Foundation)
METAP2, a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory phosphorylation by removing the amino-terminal methionine residue from nascent protein; this aminopeptidase may be overexpressed in a variety of tumor cell types.
(Fumagillin-Derived Polymer Conjugate XMT-1107, NCI Thesaurus)
Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations.
(Nucleotide Analogue GS 9219, NCI Thesaurus)
Chaperone Protein Inhibition involves interference with, or restraint of, the activities of diverse cellular proteins that noncovalently bind to nascent or unfolded polypeptides and mediate assembly/disassembly, stability, and transmembrane translocation of other polypeptides or complexes, but which are not components of those structures.
(Chaperone Protein Inhibition, NCI Thesaurus)
Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts.
(Alternate Splicing, NCI Thesaurus)
Encoded by human EEF2 Gene (EF-G/EF-2 Family), highly conserved 857-aa 95-kDa cytoplasmic Elongation Factor 2 is essential for protein synthesis and required for GTP-dependent ribosomal A-site to P-site translocation of nascent protein chains: peptidyl-tRNA is moved from the ribosome acceptor site to the next mRNA codon by hydrolysis of GTP bound to EF2.
(Elongation Factor 2, NCI Thesaurus)
As an irreversible inhibitor, beloranib blocks METAP2's functions, which include both protecting eukaryotic initiation factor 2 from inhibitory phosphorylation during translation, and by removing the amino-terminal methionine residue from nascent protein permitting the conversion of an inactive or non-functional protein to an active one.
(Beloranib, NCI Thesaurus)
In addition, it associates with CSA, CSB, or both proteins at the transcriptional pause sites to facilitate the resumption of transcript elongation without aborting the associated nascent transcript by pushing the stalled RNA polymerase II either forward or backward not only from the damaged site but also from some natural transcription pause sites.
(DNA Excision Repair Protein ERCC-5, NCI Thesaurus)
Of the billions of possible free-floating worlds thought to populate our galaxy, some may be very low-mass brown dwarfs, while others may in fact be bona fide planets, kicked out of nascent solar systems.
(Lone Planetary-Mass Object Found in Family of Stars, NASA)
