NCK Adaptor Protein 2

Encoded by human NCK2 Gene, ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, associates with tyrosine-phosphorylated growth factor receptors or their substrates. NCK2 interacts with PINCH and DOCK1. NCK2 shares 68% amino acid identity with NCK-alpha; most differences occur outside the SH2/SH3 domains. NCK2 associates with PDGF and EGF receptors via p62DOK and inhibits DNA synthesis. NCK2 binds to B ephrin cytoplasmic domains in a phosphotyrosine-dependent manner. NCK2-dependent (SH2 domain) B ephrin signaling increases FAK activity, redistributes paxillin, inhibits focal adhesions, and disassembles F-actin fibers. NCK2 SH3 domains bind proteins implicated in cytoskeletal regulation: CAP/ponsin, ABI1, dynamin, PAK1, HNRNPK, and axin. (NCI Thesaurus)

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