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NEGATIVE FEEDBACK
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Feedback in opposite phase with (decreasing) the input
Classified under:
Nouns denoting natural processes
Hypernyms ("negative feedback" is a kind of...):
feedback (the process in which part of the output of a system is returned to its input in order to regulate its further output)
Context examples:
Mimicking the negative feedback mechanism of testosterone, nandrolone decanoate also suppresses the secretion of luteinizing hormone (LH).
(Nandrolone Decanoate, NCI Thesaurus)
As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.
(Ethynodiol Diacetate, NCI Thesaurus)
Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland.
(Metyrapone, NCI Thesaurus)
Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
(p53 Signaling Pathway KEGG, NCI Thesaurus/KEGG)
Due to the negative feedback mechanism seen with progesterone, this agent also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.
(Hydroxyprogesterone Caproate, NCI Thesaurus)
The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos.
(Oocyte Meiosis Pathway, NCI Thesaurus/KEGG)
As a selective estrogen receptor modulator (SERM), enclomiphene binds to hypothalamic estrogen receptors, blocking the negative feedback of endogenous estrogens and stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus; released GnRH subsequently stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, resulting in ovulation.
(Enclomiphene Citrate, NCI Thesaurus)
Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.
(Megestrol acetate, NCI Thesaurus)
Here we illustrate the negative feedback of cyclic nucleotides (CNG)-induced membrane depolarization on Ca2+ entry.
(Ion Channels in Vascular Endothelium Pathway, NCI Thesaurus/BIOCARTA)
Blocking the negative feedback loop would potentially increase PI3K signaling and decrease therapeutic efficacy.
(pan-PI3K/mTOR Inhibitor PQR309, NCI Thesaurus)
