Neuroblastoma-Amplified Sequence

A 1352-aa 153-kDa and a 2371-aa 268-kDa isoform of Neuroblastoma-Amplified Protein are expressed in adult and fetal tissues by human NAG Gene. The 1,352-aa protein contains a C-terminal leucine zipper domain and a ribosomal protein S14 signature domain. In addition, the 2,371-aa protein contains an N-terminal leucine zipper motif, 3 putative transmembrane helices, an endoplasmic reticulum signal sequence, and 2 peroxisomal targeting signals. NAG has 2 clusters of nuclear localization signals, one in the N-terminus of the longer variant and the other in the common C-terminus. NAG shares 83 to 86% identity with orthologous mammalian proteins. The C-terminal leucine zipper and ribosomal S14 motif are not conserved in plant and nematode proteins. (NCI Thesaurus)

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