Health / Medical Topics

    Neuroendocrine Hyperplasia of the Mouse Pulmonary System

    Groups of uniform small cells with scant cytoplasm and round to oval nuclei with dense speckled chromatin form clusters thickening bronchiolar wall and/or protruding into the lumen. Not reported to occur spontaneously. Neuroendocrine hyperplasia must be differentiated from normal groups of neuroendocrine cells found more prominently in some mouse strains. (NCI Thesaurus/MMHCC)




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