Library / English Dictionary

NEUROMUSCULAR JUNCTION

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

The junction between a nerve fiber and the muscle it supplies

Synonyms:

myoneural junction; neuromuscular junction

Classified under:

Nouns denoting body parts

Hypernyms ("neuromuscular junction" is a kind of...):

synapse (the junction between two neurons (axon-to-dendrite) or between a neuron and a muscle)

Credits

 Context examples: 

Ambenonium chloride is a rapid indirect-acting cholinergic agonist that reversibly blocks the activity of acetylcholinesterase, thereby prevents acetylcholine hydrolysis and prolonging its activity on nicotinic receptors at the neuromuscular junction.

(Ambenonium Chloride, NCI Thesaurus)

The neuromuscular junction communicates action potentials from motor neurons across a synapse to skeletal muscle.

(Botulin Pathway, NCI Thesaurus/BIOCARTA)

Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain.

(Nicotine, NCI Thesaurus)

Inhibition of acetylcholinesterase results in prolonged signaling at the neuromuscular junction, and uncontrollable spasms in humans caused by nerve gas or in insects by some insecticides.

(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)

The heparan sulphate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle.

(Agrin Pathway, NCI Thesaurus/BIOCARTA)

Upon administration of the lozenge, nicotine is released and, although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine.

(Nicotine lozenge, NCI Thesaurus)

The most thoroughly examined neuregulin, neu differentiation factor NDF (AKA: neuregulin-1; NRG1; also heregulin, glial growth factor, or acetylcholine receptor-inducing activity), has been shown to play essential roles in the development of cardiac and neural tissues and also has been shown to play a role in the postsynaptic development of the neuromuscular junction.

(ErbB3 Receptor Recycling Pathway, NCI Thesaurus/BIOCARTA)

Though the exact mechanism of action of methocarbamol was not established, it's postulated to be via a mechanism similar of carbamate, inhibition of acetylcholinesterase at synapses in the autonomic nervous system, neuromuscular junction, and central nervous system.

(Methocarbamol, NCI Thesaurus)

Upon administration of the patch, nicotine is slowly released into the bloodstream and, although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine.

(Nicotine patch, NCI Thesaurus)

Although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine.

(Nicotine nasal spray, NCI Thesaurus)