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NGF
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A protein that is involved in the growth of peripheral nerve cells
Synonyms:
nerve growth factor; NGF
Classified under:
Hypernyms ("NGF" is a kind of...):
growth factor (a protein that is involved in cell differentiation and growth)
Context examples:
Beta-nerve growth factor (241 aa, ~27 kDa) is encoded by the human NGF gene.
(Beta-Nerve Growth Factor, NCI Thesaurus)
Further understanding of NGF signaling may be applied to the modulation of NGF responses in neurodegenerative conditions.
(Nerve Growth Factor Pathway, NCI Thesaurus/BIOCARTA)
NGF stimulates phosphorylation of the TRK protein.
(Nerve Growth Factor Receptor, NCI Thesaurus)
Inhibition of the NGF pathway may prevent the perception of pain and may induce analgesia.
(Fulranumab, NCI Thesaurus)
BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF).
(BTG Cell Cycle Regulation Pathway, NCI Thesaurus/BIOCARTA)
At the site of innervation, target tissues release neurotrophins including NGF, BDNF and neurotrophin-3 that stimulate the survival of the associated neuron.
(Neuronal Survival Pathway, NCI Thesaurus/BIOCARTA)
Proforms of NGF and BDNF are secreted and cleaved by plasmin serine protease and matrix metalloproteinases (MMP7, MMP3); proforms preferentially activate p75(NTR) to mediate apoptosis and mature forms activate TRK receptors to promote survival.
(Brain-Derived Neurotrophic Factor, NCI Thesaurus)
High-affinity binding of NGF requires both TrkA and p75(NTR).
(Nerve Growth Factor Pathway, NCI Thesaurus/BIOCARTA)
TRK is expressed in monocytes, suggesting that, in addition to its neurotrophic function, NGF is an immunoregulatory cytokine acting on monocytes.
(Nerve Growth Factor Receptor, NCI Thesaurus)
NGF, a neurotrophic factor that plays a key role in neuropathic and inflammatory-induced pain, promotes hyperalgesia and allodynia.
(Fulranumab, NCI Thesaurus)
