Health / Medical Topics

    Nitric oxide-releasing acetylsalicylic acid derivative

    Pronunciation

    Definition 1

    A substance being studied in the prevention of colorectal cancer. It is a form of aspirin that gives off nitric oxide gas and is less irritating to the lining of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory drug (NSAID). Also called NCX 4016. (NCI Dictionary)

    Definition 2

    A nitric oxide (NO) donating derivative of acetylsalicylic acid with anti-inflammatory, analgesic, antipyretic, antithrombotic, gastroprotective and potential antitumor activities. The acetylsalicylic acid derivative moiety of this agent inhibits the activities of cyclooxygenase (COX) I and II, preventing the formation of prostaglandins and thromboxanes. A reduction in prostaglandin synthesis accounts for this agent's anti-inflammatory, anti-pyretic and analgesic activities; a reduction in thromboxane A2 synthesis results in an irreversible inhibition of platelet aggregation. NO donation by this agent, after cleavage from the acetylsalicylic acid derivative in vivo, may protect the gastric mucosa against the damaging effects of the aspirin derivative by modulating prostaglandins. In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases and may induce apoptosis through caspase-mediated mechanisms. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind…
    Induced by lipopolysaccharide, endotoxins, and cytokines and expressed as 2 alternative isoforms in liver, retina, bone cells, and airway epithelia by human…
    Nitric oxide synthase, endothelial (1203 aa, ~133 kDa) is encoded by the human NOS3 gene. This protein plays a role in the…
    Nitric oxide synthase, brain (1434 aa, ~161 kDa) is encoded by the human NOS1 gene. This protein plays a role in both…
    Any substance that inhibits nitric oxide synthase, an enzyme that catalyzes the production of nitric oxide from L-arginine. Nitric oxide is an…
    Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact