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Nolatrexed Dihydrochloride
Definition 1
The dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. (NCI Thesaurus)
Definition 2
A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors. (NCI Dictionary)
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