Noscapine Hydrochloride

The orally available hydrochloride salt of the opioid agonist noscapine, a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and subsequently, the inhibition of mitosis and tumor cell death. Unlike other tubulin inhibitors such as the taxanes and vinca alkaloids, noscapine does not affect microtubule polymerization. (NCI Thesaurus)

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Noscapine

A phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine exerts…

NOS3 wt Allele

Human NOS3 wild-type allele is located within 7q36 and is approximately 24 kb in length. This allele, which encodes nitric-oxide synthase, endothelial…

NOS3 Gene

This gene plays a role in signal transduction, angiogenesis and platelet aggregation.

NOS2C wt Allele

Human NOS2C wild-type allele is located within 17p13.1-q25 and is approximately 8 kb in length. This allele, which encodes nitric-oxide synthase IIC…

NOS2C Gene

This gene is involved in the cell immunity/defense.

NOS2B wt Allele

Human NOS2B wild-type allele is located within 17p13.1-q25 and is approximately 9 kb in length. This allele, which encodes nitric-oxide synthase IIB…