| Health / Medical Topics |
NOTCH2 wt Allele
Human NOTCH2 wild-type allele is located within 1p13-p11 and is approximately 158 kb in length. This allele, which encodes neurogenic locus notch homolog protein 2, is involved in the mediation of cell-cell signaling. Mutation of the gene is associated with both Alagille syndrome type 2 and Hajdu-Cheney syndrome. (NCI Thesaurus)
YOU MAY ALSO LIKE
This gene plays a role in cell-cell signaling.
Human NOTCH1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 51 kb in length. This allele, which encodes…
This gene is involved in intercellular signal transduction that plays a key role in development.
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the…
The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by the…
Notch is a large cell-surface receptor that is activated by contact with membrane-bound ligands on neighboring cells. The ligands that activate…
