NOTCH3 wt Allele

Human NOTCH3 wild-type allele is located within 19p13.2-p13.1 and is approximately 41 kb in length. This allele, which encodes neurogenic locus notch homolog protein 3, is involved in both cell-cell signaling and cell differentiation. Mutation of the gene is associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (NCI Thesaurus)

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NOTCH3 Gene

This gene plays a role in both intercellular signaling and cell fate determination.

NOTCH2 wt Allele

Human NOTCH2 wild-type allele is located within 1p13-p11 and is approximately 158 kb in length. This allele, which encodes neurogenic locus notch…

NOTCH2 Gene

This gene plays a role in cell-cell signaling.

NOTCH1 wt Allele

Human NOTCH1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 51 kb in length. This allele, which encodes…

NOTCH1 Gene

This gene is involved in intercellular signal transduction that plays a key role in development.

Notch Signaling Pathway

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the…