Notch4 Protein

NOTCH4 Protein is a Drosophila Notch receptor homologue with 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region. A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling. NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice. MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis. (from OMIM 164951 and NCI) (NCI Thesaurus)

YOU MAY ALSO LIKE

NOTCH4 Gene

This gene plays a regulatory role in vascular, renal and hepatic development.

NOTCH3 wt Allele

Human NOTCH3 wild-type allele is located within 19p13.2-p13.1 and is approximately 41 kb in length. This allele, which encodes neurogenic locus notch…

NOTCH3 Gene

This gene plays a role in both intercellular signaling and cell fate determination.

NOTCH2 wt Allele

Human NOTCH2 wild-type allele is located within 1p13-p11 and is approximately 158 kb in length. This allele, which encodes neurogenic locus notch…

NOTCH2 Gene

This gene plays a role in cell-cell signaling.

NOTCH1 wt Allele

Human NOTCH1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 51 kb in length. This allele, which encodes…