Notch Homolog 1

Expressed in adult/fetal tissues by human NOTCH1 Gene (Notch Family), 2556-aa 273-kDa phosphorylated type 1 transmembrane Notch Homolog 1 contains 36 extracellular EGF domains, 3 Lin/Notch repeats, and multiple intracellular domains, including 5 ANK repeats. Cleaved by a Golgi furin-like convertase, cell surface Notch protein is a disulfide linked N-/C-terminal heterodimeric receptor for membrane-bound Jagged1, Jagged2, Delta1, and Serrate on adjacent cells that activates an conserved intercellular signaling pathway (lateral inhibition) to regulate cell-fate determination, differentiation, proliferation, and apoptotic programs. Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes. NOTCH1 interacts with DTX1 and DTX2 and may regulate thymic lymphocyte maturation. (NCI Thesaurus)

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