NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes

Exosomes loaded with non-small cell lung cancer (NSCLC)-specific antigens, with potential immunostimulating and antineoplastic activities. Exosomes derived from autologous maturing dendritic cells (DCs) are pulsed with HLA-DP04-restricted MAGE-3, and HLA-A02-restricted peptides NY-ESO-1, MAGE-1, MAGE-3, and MART-1. Upon vaccination, these exosomes may stimulate natural killer (NK) cell activation and proliferation, restoration of NKG2D expression on NK cells, and antigen-specific T-cell responses. This may eventually lead to inhibition of tumor cell proliferation in NSCLC expressing these specific tumor antigens. These exosomes, nanovesicles secreted from DCs, are embedded with molecules necessary for potent immune responses on the exosomal surface, such as MHC class II molecules, CD40, ICAM-1, IL-15Ralpha, and NKG2D ligands. (NCI Thesaurus)

YOU MAY ALSO LIKE

NSC Number

A numeric identifier for substances submitted to the National Cancer Institute (NCI) for testing and evaluation. It is named after the Cancer…

NSC Generic Product Identifier

An NSC code identifier issued for a generic product.

NSC 655649

A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called antitumor antibiotics and…

NSAID

A drug that decreases fever, swelling, pain, and redness. Also called nonsteroidal anti-inflammatory drug.

NRXN1 wt Allele

Human NRXN1 wild-type allele is located in the vicinity of 2p16.3 and is approximately 1112 kb in length. This allele, which encodes…

NRXN1 Gene

This gene is involved in cell recognition, cellular adhesion and signal transduction.