| Health / Medical Topics |
Nuclear Receptor
Proteins that regulate transcription via interaction with chromatin and basal transcription machinery at the promoter regions of genes. Nuclear receptors are ligand-dependent transcription factors including steroids, retinoids, vitamin D, unliganded thyroid hormone, and orphan receptors (unknown ligands). Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulate positive or negative receptor activity. (NCI Thesaurus)
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An octagonal opening, about 70 nm across, where the inner and outer membranes of the nuclear envelope are continuous.
Having nuclei with various distinct forms.
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