Nucleolin Antagonist IPP-204106N

A synthetic, multivalent, lysine-rich, pseudopeptide and nucleolin antagonist with potential anti-angiogenic, antineoplastic and pro-apoptotic activities. Upon administration, IPP-204106N antagonizes nucleolin leading to a downregulation of cell-surface nucleolin; preventing the binding of certain growth promoting ligands to nucleolin may suppress tumor cell proliferation and angiogenesis. In addition, IPP-204106N is able to translocate to the nucleolus and bind to nucleolar nucleolin. This prevents nucleolin from binding to and stabilizing mRNA of the anti-apoptotic Bcl2; destabilizing Bcl2 mRNA leads to a reduction in Bcl2 protein synthesis and induces apoptosis. Further, this agent can antagonize nucleophosmin. Nucleolin, a nucleolar phosphoprotein, is overexpressed on the cell surface of certain cancer cells and binds ligands involved in cell proliferation, adhesion and angiogenesis. (NCI Thesaurus)

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Nucleolin

Nucleolin (710 aa, ~77 kDa) is encoded by the human NCL gene. This protein is involved in both chromatin decondensation and ribosome…

Nucleolar-Associated Chromatin

Heterochromatin that is associated with the nucleolus.

Nucleolar Organizer Region

Nucleolar organizer regions (NORs), which are loops of DNA containing ribosomal RNA genes, have been shown to correlate with cell proliferation and…

Nucleolar Granular Material

A collection of preribosomes in the nucleolus.

Nucleolar Fibrillar Material

A thread-like complex of ribosomal components including ribosomal RNA, in various stages of transcription, and associated proteins.

Nucleocytoplasmic Transport

The transport of material in and out of the nucleus through the nuclear membrane.