Nucleoporin 214kDa

Expressed in thymus, spleen, bone marrow, kidney, brain, and testis by human NUP214 Gene (FG-Repeat NUP Family), 2090-aa 214-kDa homodimeric Nuclear Pore Complex Protein NUP214, likely glycosylated, contains F-G repeats and is associated with cytoplasmic filaments and the cytoplasmic face of the nuclear pore complex. NUP214 is required for proper cell cycle progression and, as a nuclear pore component, may regulate nucleocytoplasmic transport by serving as a docking site in receptor-mediated nuclear import. NUP214 interacts with DDX19 and NUP88. Involved in some cases of leukemia, chromosomal translocation t(6;9)(p23;q34) results in a DEK-NUP214 fusion gene, while chromosomal translocation t(6;9)(q21;q34.1) involves a NUP214/SET gene fusion. (NCI Thesaurus)

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